The latest trends in improving CAR-T cell therapy: from leukemia to solid malignant tumors
نویسندگان
چکیده
CAR-Т cell therapy with the use of cytotoxic lymphocytes chimeric antigen receptors occupies an important place among modern approaches to cancer treatment. This has established itself as effective method treatment CD19+ acute lymphoblastic leukemia. Nevertheless, recurrences illness are not uncommon; solid tumors genetically engineered shows modest results and it is accompanied by high toxicity. One thing, however, certain: great potential in further improving structure functions Т help greatly increase efficiency antitumor The review includes current data on different generations trends therapy. It also fundamental platform for formation ideology cells malignant tumors.
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ژورنال
عنوان ژورنال: Rossijskij žurnal detskoj gematologii i onkologii
سال: 2021
ISSN: ['2413-5496', '2311-1267']
DOI: https://doi.org/10.21682/2311-1267-2021-8-2-84-95